Beta-glucan peptide (BGP)

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Dectin-1 Agonist - Beta-glucan from Trametes versicolor
Beta-glucan peptide (BGP)

Beta-glucan peptide (BGP) is a high molecular weight (~100 kDa) polysaccharide extracted from the fungus Trametes versicolor.

BGP consists of a highly ramified glucan portion, comprising a beta 1-4 main chain and beta 1-3 side chain, with beta 1-6 side chains covalently linked to a polypeptide portion rich in aspartic, glutamic and other amino acids.

BGP activates murine macrophages and HEK-Blue™ Dectin-1 cells. Detection of β-glucans by Dectin-1 receptor leads to the CARD9-dependent activation of NF-κB and MAP kinases.

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