HKCA

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Dectin-1 Agonist - Heat-killed C. albicans
HKCA

HKCA activates the β-glucan specific dectin-1 receptor, which is expressed on phagocytes. β-Glucans are glucose polymers found in the cell walls of fungi, such as zymosan (a cell wall preparation of Saccharomyces cerevisiae) and Candida albicans.

Dectin-1 binds and internalizes β-glucans and mediates the activation of NF-κB and subsequent secretion of proinflammatory cytokines.

HKCA is a heat-killed preparation of C.albicans. HKCA activates the β-glucan specific dectin-1 receptor, which is expressed on phagocytes [1].

β-Glucans are glucose polymers found in the cell walls of fungi, such as zymosan (a cell wall preparation of Saccharomyces cerevisiae) and Candida albicans.

Dectin-1 binds and internalizes β-glucans and mediates the production of reactive oxygen species (ROS), activation of NF-κB and subsequent secretion of proinflammatory cytokines.

However, it is now clear that its β-glucan moiety triggers NF-κB activation only through Dectin-1 as treatment with hot alkali or organic solvents abrogates the TLR2-dependent response [2,3].

References:

  1. Brown GD. et al., 2003. Dectin-1 mediates the biological effects of beta-glucans. J Exp Med. 197: 1119- 24.
  2. Gantner BN. et al., 2003. Collaborative induction of inflammatory respons- es by dectin-1 and Toll- likereceptor 2. J Exp Med. 197: 1107- 17.
  3. ikeda Y. et al., 2008. Dissociation of Toll- like receptor 2-mediated innate immune response to Zymosan by organic solvent-treatment without loss of Dectin-1 reactivity.Biol Pharm Bull.31: 13-8.

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