WGP Dispersible (WGP® Dispersible, Biothera), whole glucan particles, is a particulate Saccharomyces cerevisiae β-glucan preparation.
It consists of hollow yeast cell wall “ghosts” composed primarily of long polymers of β-1,3 glucose obtained after a series of alkaline and acid extractions from S. cerevisiae cell wall [1].
In contrast to Zymosan, WGP lacks TLR-stimulating activity [2]. Similarly to Zymosan, WGP induces Dectin-1-dependent responses, including phagocytosis and induction of TNF-α, IL-6 and ROS by macrophages and dendritic cells.
References:
- Li B. et al., 2007. Yeast glucan particles activate murine resident macrophages to secrete proinflammatory cytokines via MyD88- and Syk kinase-dependent pathways. Clin Immunol. 124(2):170-81.
- Goodridge HS. et al., 2011. Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature. 472(7344):471-5.
