WGP Soluble

WGP Soluble (WGP® Soluble, Biothera) is a pure soluble WGP preparation.

Similarly to particulate WGP, WGP Soluble binds efficiently Dectin-1, however it is incapable of activating the receptor [1].

Furthermore, WGP Soluble is able to significantly block the binding of WGP to macrophages and its immunostimulatory effect [2].

References:

1. Goodridge HS. et al., 2011. Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature. 472(7344):471-5.
2. Li B. et al., 2007. Yeast glucan particles activate murine resident macrophages to secrete proinflammatory cytokines via MyD88- and Syk kinase-dependent pathways. Clin Immunol. 124(2):170-81.