TDB-HS15

Trehalose-6,6-dibehenate (TDB) is a non-toxic synthetic analogue of trehalose-6,6-dimycolate (TDM, also known as cord factor), which is the most studied immunostimulatory component of Mycobacterium tuberculosis.

TDB is an effective adjuvant for Th1/Th17 vaccination. TDB was found to rely on Mincle, Syk and Card9 for its adjuvant activity [1]. TDB is a poorly soluble compound and thus was formulated with Kolliphor® HS 15, a potent low-toxicity non-ionic solubilizer, to generate TDB-HS15, which is particularly suitable for in vivo studies.

TDB-HS15 is a strong activator of NF-kB in a Mincle-dependent manner.

Kolliphor® HS 15 (former tradename Solutol® HS 15) is a registered trademark of BASF.

Reference:

1. Schoenen H, et al., 2010. Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate. J Immunol. ; 184(6):2756-60.