Nigericin

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NLRP3 Inflammasome Inducer - Nigericin, sodium salt
Nigericin

Nigericin is a microbial toxin derived from the Gram-positive bacteria Streptomyces hygroscopicus. It induces the release of IL-1β in response to the activation of the NLRP3 (also known as NALP3 or cryopyrin) inflammasome [1]. The NLRP3 inflammasome is a caspase‑1-activating complex comprising the NLR protein NLRP3 and the adaptor ASC required for the maturation and secretion of IL-1β [2].

Nigericin acts as a potassium ionophore. It probably activates NLRP3 through its ionophore function which allows the intracellular K+ efflux across the membrane [3]. Whether the formation of non‑selective pannexin-1 pores also contributes to NLRP3 activation upon Nigericin treatment remains unclear [4]

Key features of Nigericin:

  • Inducer of the NLRP3 inflammasome
  • Potassium ionophore
  • Each lot is functionally tested

Read our review on the NLRP3 inflammasome.

Download our Practical guide on Inflammasomes.

References:

  1. Mariathasan S. et al., 2006. Cryopyrin activates the inflammasome and ATP. Nature 440;228-32.
  2. Martinon F. & Tschopp J., 2004. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell. 117(5):561-74.
  3. Muñoz-Planillo R. et al., 2013. K+ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity. 38(6):1142-53..
  4. Pelegrin P, & Surprenant A., 2007. Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway. J Biol Chem. 282(4):2386-94.

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