PustulanInvivoGen Kontakt z doradcą
Pustulan is a median molecular weight (20 kDa), linear (1-6) linked β-D-glucan from lichen Lasallia pustulata.
Pustulan is recognized by the membrane bound Dectin-1, a C-type lectin-like pattern recognition receptor .
Detection of β-glucans by Dectin-1 receptor leads to the CARD9-dependent activation of NF-κB and MAP kinases.
Studies have shown that pustulan can stimulate innate immune responses, inducing heat shock protein expression, eliciting phagocytosis , and production of proinflammatory cytokines .
- Willment Ja. et al., 2001. Characterization of the human beta -glucan receptor and its alternatively spliced isoforms. J Biol Chem. 276(47):43818- 23.
- Goodridge HS. et al., 2009. Beta-glucan recognition by the innate immune system. Immunol Rev. 230(1):38-50.
- Iubin-Bejerano I. et al., 2007. Phagocytosis by human neutrophils is stimulated by a unique fungal cell wall component. Cell Host Microbe. 2(1):55-67.
- Noss I. et al., 2013. Comparison of the potency of a variety of β-glucans to induce cytokine production in human whole blood. Innate Immun. 19(1):10-9.