Anti-hIFNγ-IgA is a chimeric monoclonal antibody specific for human interferon-gamma (hIFN-γ). It was generated by combining the constant domains of the human IgA molecule with murine variable regions.
Anti-hIFNγ-IgA has been selected for its ability to efficiently neutralize the biological activity of hIFN-γ. The neutralizing activity of this IgA antibody was determined using cells that respond to hIFN-γ.
It was found to be significantly higher than the neutralizing activity of the corresponding IgG isotype.
