InvivoGen provides a collection of monoclonal and polyclonal antibodies targeting human Toll-like receptor 4 (TLR4) for applications such as neutralization and detection.
TLR4 is the receptor for bacterial lipopolysaccharide (LPS) and lipid A, its toxic moiety [1]. However, TLR4 alone is not sufficient to confer LPS responsiveness. TLR4 requires both MD-2 and CD14 to functionally interact with LPS [2, 3]. Ultimately, this leads to the activation of NF-κB and the production of proinflammatory cytokines [3].
References
- Chow J. et al., 1999. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem 274: 10689-92.
- Shimazu R. et al., 1999. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med, 189(11): 1777-82.
- Shuto T. et al., 2005. Membrane-anchored CD14 is required for LPS-induced TLR4 endocytosis in TLR4/MD-2/CD14 overexpressing CHO cells. Biochem Biophys Res Commun 338: 1402-9.
