Hyperion™ Imaging System

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Visualize the complex spatial biology of the tissue microenvironment with Imaging Mass Cytometry. Gain unprecedented single-cell insights into the intricate spatial relationships of cells, pathways and phenotypes in the tissue microenvironment in the context of disease.

Technology Hyperion™ Imaging System

Imaging Mass Cytometry™ (IMC™) with the Hyperion™ Imaging System allows the generation of novel research hypotheses by surveying a high number of protein markers in one scan, saving precious sample, while employing proven CyTOF® technology. A precisely directed laser beam focused at 1 μm collects biological samples stained with metal-tagged Maxpar® antibodies from a region of interest. Discrete signals from each ionized metal tag are detected based on differences in mass instead of wavelength. Thus, IMC eliminates autofluorescence and achieves uniform staining with minimal background. Large panels can be designed with minimal concern about antibody order or label assignment. The Hyperion Imaging System is the ideal solution when you work with heterogeneous biology where assessing key spatial information is critical to driving a deeper understanding of healthy and disease states. Use the system to gain a better understanding of immunotherapy responses that could ultimately help extend patient lives.

Workflow Hyperion™ Imaging System

Design. Design panels using pathologist-verified Maxpar antibodies conjugated to metal tags.
Stain. Stain tissues (FFPE or frozen) using familiar immunohistochemistry protocols.
Image. Image up to 40 protein markers in one scan at single-cell resolution using the Hyperion Imaging System.
Analyze. Analyze images in minutes using the MCD™ Viewer and easily export the resulting files for secondary analysis.

PUBLICATIONS

Join the hundreds of researchers who have gained deep spatial biology insights IMC to phenotype, stratify, discover biomarkers and gain therapeutic insights that address significant translational and clinical research questions.

ESMO Open | 2022 Jan 5
Targeting immunoliposomes to EGFR-positive glioblastoma.
Arthritis Res Ther | 2022 Jan 4
Cannabinoid type 2 receptor (CB2R) distribution in dermatomyositis skin and peripheral blood mononuclear cells (PBMCs) and in vivo effects of LenabasumTM
Int J Mol Sci | 2021 Dec 25
Multiple Immunostainings with Different Epitope Retrievals—The FOLGAS Protocol
biorxiv | 2021 Dec 20
Disrupted Peyer’s patch microanatomy in COVID-19 including germinal centre atrophy independent of local virus
Front Immunol | 2021 Nov 19
B Cell Signatures Distinguish Cutaneous Lupus Erythematosus Subtypes and the Presence of Systemic Disease Activity

Software

Insight made easy. Get meaningful results from your research with our complete offering of automated, efficient data analysis software. Whether you're evaluating single cells, real-time PCR results or genotyping data, our advanced software programs include standard analysis techniques as well as superior interpretation methods to help you make the most of your work.