Anti-dCD20c1-dIgG2 is a chimeric monoclonal antibody specific for dog CD20 (dCD20). TIn flow cytometry applications, this antibody has exhibited weak cross-reactivity with human CD20. Reactivity with other species has not been tested.
It has been produced in CHO cells and purified by affinity chromatography with protein A.
Anti-dCD20c1-dIgG2 was generated by combining the constant domains of the dog IgG2 molecule with the variable regions of Anti-dCD20c1-mIgG2a.
Anti-dCD20c1-mIgG2a has been selected for its ability to bind dCD20 and induce complement-dependent cytotoxicity (CDC).