Anti-β-Gal-hIgG3

Anti-β-Gal-hIgG3 features the constant region of the human IgG3 isotype and the variable region of Mouse IgG2a Control. Mouse IgG2a Control is a mouse IgG2a monoclonal antibody that targets E. coli β-galactosidase (β-Gal). This antibody was generated by DNA immunization with a plasmid expressing the β-Gal gene in Swiss mice. It can be used as an isotype control for human IgG3 antibodies.

Human IgG3 is the third most common antibody present in serum. Human IgG3 is very susceptible to cleavage by proteolytic enzymes, due an extended hinge region. Human IgG3 displays strong antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC).

Anti-β-Gal-hIgG3 was generated by recombinant DNA technology. It has been produced in CHO cells and purified by affinity  chromatography.