Peptide M / Agarose

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Agarose for IgA1 and IgA2 purification
Peptide M / Agarose

Peptide M is a 50 aa synthetic peptide derived from a streptococcal M protein containing an additional C-terminal cysteine residue.

Peptide M binds monomeric and dimeric human IgA of both subclasses (IgA1 and IgA2) with high specificity and affinity.

It also binds bovine IgA but not murine IgA. Peptide M binding occurs at a site in IgA-Fc conserved in human IgA1 and IgA2 and bovine IgA but not in mouse IgA.

Peptide M can be used for single-step affinity purification of IgA and for specific detection of antigen-bound IgA.

Reference:

  1. Sandin C. et al., 2002. Isolation and detection of human IgA using a streptococcal IgA binding peptide. J Immunol. 169(3):1357-64.

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