Anti-hCD20 isotype family

InvivoGen's anti-hCD20 isotype family features the variable region of either Rituximab, Ofatumumab or Obinutuzumab clinical monoclonal antibodies (mAbs), which all target the human CD20 antigen (hCD20).
Our anti-hCD20 antibodies feature either native or engineered constant regions (Fc), which results in different capacities to exert biological functions such as complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC), or apoptosis.

• Rituximab is a type I (first generation) mouse/human chimeric IgG1 mAb.
• Ofatumumab is a type I (first generation) fully human IgG1 mAb.
• Obinutuzumab is a type II (second generation) non-fucosylated, fully humanized IgG1 mAb.

InvivoGen's anti-hCD20 antibodies are generated by recombinant DNA technology, produced in CHO cells, and purified by affinity chromatography according to their isotype (protein G for IgG peptide M for IgA, and protein L for IgE/IgM).