Anti-hACE2 mouse IgG2b

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Anti-human ACE2 antibody - Mouse IgG2b isotype
Anti-hACE2 mouse IgG2b

Antibody description

InvivoGen provides a mouse monoclonal antibody (mAb) featuring: 

  • a variable region that specifically targets the humanACE2 transmembrane protein, established as the SARS-CoV-2 receptor [1]
  • the mouse IgG2b constant region

The Anti-hACE2-mIgG2b antibody was obtained following Swiss mice immunization with DNA encoding hACE2. It is produced in hybridoma cells and purified by affinity chromatography with protein A.

Application

  • Monitoring cell surface expression of human ACE2 in primary cells or engineered cell lines by FACS (see Figure)

Quality control

  • Isotype confirmed by ELISA
  • Functionality validated by FACS using HEK-Bue™ hACE2-TMPRSS2 cells

Read our reviews discussing SARS-CoV-2

References

  1. Hoffmann M. et al., 2020. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 181:1-16.

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