Pepinh-MYD

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TLR signaling inhibitor - MyD88 inhibitory peptide
Pepinh-MYD

Pepinh-MYD is a 26 aa peptide that blocks MyD88 signaling by inhibiting its homodimerization through binding.

Pepinh-MYD contains a sequence from the MyD88 TIR homodimerization domain (RDVLPGT) [1] preceeded by a protein transduction sequence (RQIKIWFQNRRMKWKK) derived from antennapedia which enables the peptide to translocate through the cell membrane [2].

Pepinh-MYD is provided with Pepinh-Control, a control peptide [3].

References:

  1. loiarro M. et al., 2005. Peptide-mediated Interference of TIR Domain Dimerization in MyD88 Inhibits Interleukin-1-dependent Activation of NF-{kappa}B. J. Biol. Chem., 280: 15809-14.
  2. Derossi D. et al., 1994. The third helix of the Antennapedia homeodomain translocates through biological membranes. J. Biol. Chem., 269: 10444-50.
  3. Toshchakov V. et al., 2005. Differential Involvement of BB Loops of Toll-IL-1 Resistance (TIR) Domain-Containing Adapter Proteins in TLR4- versus TLR2-Mediated Signal Transduction. J. Immunol., 175: 494 - 500.

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