Pepinh-TRIF

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TLR signaling inhibitor - TRIF inhibitory peptide
Pepinh-TRIF

Pepinh-TRIF is a 30 aa peptide that blocks TRIF signaling by interfering with TLR-TRIF interaction.

PepinhTRIF contains the 14 aa that correspond to the sequence of the BB loop of TRIF (FCEEFQVPGRGELH) [1] linked to the cell-penetrating segment of the antennapedia homoedomain (RQIKIWFQNRRMKWKK) [2].

Pepinh TRIF is provided with Pepinh-Control, a control peptide [1].

References:

  1. Toshchakov V. et al., 2005. Differential Involvement of BB Loops of Toll-IL-1 Resistance (TIR) Domain-Containing Adapter Proteins in TLR4- versus TLR2-Mediated Signal Transduction. J. Immunol., 175: 494 - 500.
  2. Derossi D. et al., 1994. The third helix of the Antennapedia homeodomain translocates through biological membranes. J. Biol. Chem., 269: 10444-50.

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