Interferon-gamma (IFN-γ), a Type II interferon, is secreted from CD4+ T-helper 1 (Th1) cells and activated natural killer (NK) cells. It plays a role in activating lymphocytes to enhance anti-microbial and anti-tumor effects. In addition, IFN-γ plays a role in regulating the proliferation, differentiation, and response of lymphocyte subsets.
Recombinant human IFN-γ (rhIFN-γ) produced in Escherichia coli is a single, non-glycosylated, polypeptide chain containing 144 amino acids and having a molecular mass of 16879 Daltons.
rhIFN-γ is used to induce its cognate signalling pathway in HEK-Blue™ IFN-γ cells.
