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oCelloScope™ – Live Cell Imaging System

Do you know how your cells develope?

With oCelloScope™ you get a deeper insight and more information about your cells with real-time kinetic data. oCelloScope automatically acquires and analyzes images in standard microtitter plates, and frees up researchers’ time, increases sample throughput, and delivers richer data.

OPIS

oCelloScope™ is a unique live-cell imaging system for sensitive and detailed monitoring of biological growth and development. The oCelloScope system integrates 3 key features:

  • Unique proprietary scanning technology, FluidScopeTM
  • Powerful image analysis software
  • Precision mechanical engineering

Together the features provides detailed information and enables researchers to set up high-throughput testing and robust time-lapse studies.

How can you benefit from  live-cell image analysis with oCelloScope?

By combining continuous real-time imaging and powerful image analysis software with oCelloScope:

  • You will never miss a data point again
  • Capture and profile time dependent events
  • Analyze microbial growth and development
  • Visualize and validate the results with images and videos

oCelloScope Workflow

With oCelloScope and the powerful UniExplorer software your research are supported day and night.

Make your experiment in any environment

  • oCelloScope fits inside your Incubator or anaerobic chamber
  • Compatible with standard microtiter plates, from 6 to 96 wells

oCelloScope Workflow

With oCelloScope and the powerful UniExplorer software your research are supported day and night.

Make your experiment in any environment

  • oCelloScope fits inside your Incubator or anaerobic chamber
  • Compatible with standard microtiter plates, from 6 to 96 wells

Acquire images for as long as you like

  • Automatically acquire images for hours, days or weeks
  • Use UniExplorer’s continue mode for running multiple long-term experiments simultaneously

View and Analyze in real-time

  • Follow you experiment in real-time with visualization of images and analysis
  • Get a instant overview of your full 96-well plate
  • Analyse single cells and mixed cultures

FluidScopeTM scanning technology

oCelloScope is based on a unique optical scanning technology FluidScopeTM combining optical techniques such as phase contrast, brightfield and confocal-like microscopy.

Together with advanced image processing algorithms, the FluidScopeTM technology provides:

  • Fast scanning of a volume in the sample
  • Greater freedom of operation with multiple Z-layers acquired simultaneously
  • Detailed 3D information at a single cell level
  • Requires no pre-treatment, staining or additional reagents

Applications

oCelloScope is used for several applications within real-time cell monitoring.  Spore germentation, Cell morphology, Cell proliferation & migration, Antimicrobial Suseptibility Testing & Growth Kinetics.

  • Microbiology research
  • Antimicrobial susceptibility testing (AST)/MIC determination
  • Automated monitoring and analysis of fungal growth
  • Real-time monitoring of morphological plasticity
  • Drug development

oCelloScope – 250 times more sensitive than standard OD plate reader

oCelloScope’s enhanced imaging technology provides greater operational flexibility at both high and low concentrations  which helps you to detect the early stages of microbial growth. With the built-in image analysis algorithms, a factor of 250 times greater sensitivity can be achieved with oCelloScope compared to OD.

A comparison study between the Thermo-Fisher Scientific VarioSkan plate reader and oCelloScope have been made, measuring the growth of E. coli every 15 min. The minimum detection limit of the OD measurement was 2·106 CFU/ml.

In contrast, with a start inoculum of 103 CFU/ml, our algorithm detects the bacterial growth after 45 min, corresponding to 8·103 CFU/ml, a factor of 250 times greater sensitivity than the minimum detection limit obtained by the VarioSkan plate reader.

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